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fraxinus excelsior medicinal uses

Posté par le 1 décembre 2020

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Fraxinus Excelsior. Scientists have described antiplasmodium potential from variety of plant extracts [98]. Stem bark, root bark, and leave extract of this plant have wide applications in traditional folk medicines since ancient times.Fraxinus plant derivative analogs along with pharmacodynamics and pharmacokinetics may also strengthen future ad… Its uses as a medicinal herb were already known by the Greek physician Hippocrates (460-377 B.C.). Committee on Herbal Medicinal Products (HMPC) Assessment report on Fraxinus excelsior L. and Fraxinus angustifolia Vahl, folium . Results. Protective hypotensive effects of Fraxinus excelsior extract were evaluated in spontaneously hypertensive and normotensive rats and oral administration of 20 mg/kg/day for about 3 weeks resulted in significant decrease in systolic blood pressure (SBP) [96]. Much remains to be discovered about MOA as a propitious therapeutic agent for inflammatory diseases [59]. Fraxinus excelsior é uma espécie de árvores da família das Oleaceae, conhecida pelo nome comum de freixo. It is hardy to zone (UK) 4 and is not frost tender. There is a need to identify the toxicological limits for certain organs like liver and kidney. Nyugat-palearktikus faj: az északi félteke mérsékelt övi erdeiben él. Treatment of bacterial cultures (Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus lactis, Escherichia coli, and Mycobacterium phlei) with plant extracts using microplate resazurin assay for screening showed that Fraxinus pennsylvanicca exhibits notable antibacterial activities with MICs ranging from 62.5 to 1000 μg/ml [84]. His work and botany passion has made The Herbal Resource what it is. In vitro studies to check the effects of lipo and hydrophilic extract from the bark of Fraxinus excelsior on the growth of asexual stages of Plasmodium falciparum suggest that it has significant inhibitory effects on the development of asexual stages of Plasmodium falciparum [99]. Even today it is sometimes known as the 'Venus of the woods'. Fraxinus excelsior (FE), locally known as “l’ssane l’ousfour”, is a native shrub widely distributed throughout the south-eastern region of Morocco (Tafilalet). This website uses cookies to improve your experience while you navigate through the website. Future efforts are required for the systematic identification of molecular targets for different compounds isolated from Fraxinus plant to enhance the possibilities of acquiring breakthrough vision in the field. É uma árvore de solos frescos e profundos, de porte médio, que pode atingir cerca de 25 metros de altura.A casca tem sulcos profundos, verticais e é castanha escura acinzentada. Fraxinus excelsior, known as the ash, or European ash or common ash to distinguish it from other types of ash, is a flowering plant species in the olive family Oleaceae.It is native throughout mainland Europe east to the Caucasus and Alborz mountains, and the British Isles which determine its western boundary. The leaves should be gathered in June, well dried and stored in airtight containers. A Fraxinus excelsior L. seeds/fruits extract benefits glucose homeostasis and adiposity related markers in elderly overweight/obese subjects: A longitudinal, randomized, crossover, double-blind, placebo-controlled nutritional intervention study. [39]. You also have the option to opt-out of these cookies. The leaves of the fraxinus excelsior tree have a reportedly diuretic and purgative effect. Free radicals have capability to interact with cellular components and thus causing DNA damage, lipid peroxidation, and protein injuries [77]. A. Oyagbemi, “Hepatoprotective and in vivo antioxidant activities of ethanolic extract of whole fruit of, W.-H. Peng, Y.-C. Tien, C.-Y. 1). Phytochemicals obtained from medicinal plants, herbs, seeds, and fruits such as phenolic compounds (terpenoids, flavonoids, and carotenoids) have shown promising effects in suppressing proliferation and thus are anticarcinogenic [62]. General Notes. We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. Middle-aged Common Ash. Review articles are excluded from this waiver policy. The ash tree was thought to have medicinal and mystical properties and the wood was burned to ward off evil spirits. This review suggests that this plant has extremely important medicinal utilization but further supporting studies and scientific experimentations are mandatory to determine its specific intracellular targets and site of action to completely figure out its pharmacological applications. Further studies are required with more microbial species to assemble data related to Fraxinus plant that can act as potential antimicrobial agent. The molecular mechanism and exact protein targets of potent bioactive molecules from Fraxinus plant also deserve to be further investigated. Huang et al., “Fraxinus rhynchophylla ethanol extract attenuates carbon tetrachloride-induced liver fibrosis in rats via down-regulating the expressions of uPA, MMP-2, MMP-9 and TIMP-1,”, U. Rohnert, W. Schneider, and E. F. Elstner, “Superoxide-dependent and -independent nitrite formation from hydroxylamine: inhibition by plant extracts,”, Y.-S. Lee, S.-H. Han, S.-H. Lee et al., “Synergistic effect of tetrandrine and ethidium bromide against methicillin-resistant Staphylococcus aureus (MRSA),”, J. Vandal, M. M. Abou-Zaid, G. Ferroni, and L. G. Leduc, “Antimicrobial activity of natural products from the flora of Northern Ontario, Canada,”, H. Wang, D. Zou, K. Xie, and M. Xie, “Antibacterial mechanism of fraxetin against Staphylococcus aureus,”, A. Wąsik and L. Antkiewicz-Michaluk, “The mechanism of neuroprotective action of natural compounds,”, L. Zhang, L. Hao, H. Wang et al., “Neuroprotective effect of resveratrol against glutamate-induced excitotoxicity,”, Y.-L. Lan, J. Zhao, and S. Li, “Estrogen receptors’ neuroprotective effect against glutamate-induced neurotoxicity,”, S. Pourkhodadad, M. Alirezaei, M. Moghaddasi et al., “Neuroprotective effects of oleuropein against cognitive dysfunction induced by colchicine in hippocampal CA1 area in rats,”, E.-J. With regard to ongoing investigations on Fraxinus plant’s biological applications further scientific experimentations and safety profiling are required to make understandings more clear and obvious in the treatment and prevention of various diseases. Stimulation of intrinsic caspase pathway and downregulation of cellular GSH in K562 lead to induction of apoptosis [56]. Esculetin (coumarin) isolated from Fraxinus rhynchophylla notably meliorated CCl4 induced hepatic toxicity by downregulating the aspartate aminotransferase and serum alanine aminotransferase and via upregulation of GSH-Px, SOD, and CAT and thus prevented the pathological condition associated with tissue injury [43]. Researchers have described a wide variety of plant extracts that have hepatoprotective activities usually associated with antioxidant activity as excessive production of free radicals overpowers the natural protective system causing hepatic damage [78–80]. Its tremendous range of pharmacotherapeutic properties has been well documented including anticancer, anti-inflammatory, antioxidant, antimicrobial, and neuroprotective. Fraxinus excelsior L. seed extract was obtained by an industrial process (FraxiPure™, batch # 347/53/A7; reference # 149251, Naturex SA, Site d’Agroparc BP 1218, 84911 Avignon Cedex 9, France) according to the traditional method used in Morocco (Eddouks and Maghrani, 2004, Maghrani et al., 2004, Eddouks et al., 2005). Protective products originated from natural substances mainly from plants as alternative to synthetic fungicides is the spotlight issue nowadays [92]. Rutin isolated from Fraxinus angustifolia have notable radical scavenging activity via inhibition of ethane release from Fenton-type oxidants induced 1-keto-4-methylthiobutyrate (KMB) and inhibition of nitrogen monoxide (NO) release from hydroxylamine [82]. Gundermann and J. Müller, “Phytodolor®—effects and efficacy of a herbal medicine,”, N.-Y. But opting out of some of these cookies may affect your browsing experience. De Boer, “Traditional use of medicinal plants among Kalasha, Ismaeli and Sunni groups in Chitral District, Khyber Pakhtunkhwa province, Pakistan,”, M. Torres, O. Palomares, J. Quiralte, G. Pauli, R. Rodríguez, and M. Villalba, “An enzymatically active, J. F. Fernandez-Manjarres, P. R. Gerard, J. Dufour, C. Raquin, and N. Frascaria-Lacoste, “Differential patterns of morphological and molecular hybridization between Fraxinus excelsior L. and Fraxinus angustifolia Vahl (Oleaceae) in eastern and western France,”, S. R. Tanis and D. G. McCullough, “Host resistance of five fraxinus species to Agrilus planipennis (Coleoptera: Buprestidae) and effects of paclobutrazol and fertilization,”, D. D. Hinsinger, M. Gaudeul, A. Couloux, J. Bousquet, and N. Frascaria-Lacoste, “The phylogeography of Eurasian Fraxinus species reveals ancient transcontinental reticulation,”, P.-Q. Herbal extracts that have important role in the regulation of immunity can serve as effective and secure medicine against toxoplasmosis [101]. The Plants Database includes the following 22 species of Fraxinus . Kidney stones. Ku et al., “Syringin from stem bark of fraxinus rhynchophylla protects a, D.-L. Zhao, L.-B. Medicinal Plant Common Ash. Zou, S. Lin, J.-G. Shi, and H.-B. The first record of sophisticated medicinal system from natural products dates back to 2600 BC in Mesopotamia, consisting of about 1000 medicines derived from botanical compounds and plant derivatives [5]. In northern areas of Pakistan, root bark and leaves of Fraxinus plant have been traditionally used for the cure of malaria and pneumonia [27]. Oral administration of ethanolic extract from Fraxinus rhynchophylla [FR (EtOH)] against CCl4 induced hepatic fibrosis resulted in protective effects by its free radical scavenging ability against hepatocellular fibrosis in rats. This potentially efficacious pharmacological drug candidate should be used for new drug discovery in future. Click below on a thumbnail map or name for species profiles. Príhoda, Antonín, Ladislav Urban & Vera Nicová: The following two tabs change content below. The names found have these generic epithets: Fraxinus; species epithets begin with: E; The results can also be downloaded as a CSV file (Unicode UTF-8 encoding).. See … 94 plant name records match your search criteria Fraxinus excelsior.The results are below. However, the results are not sufficient and should be approved by related tests along with clinical trials. Identification and isolation of lead structures from hydroethanolic extract for novel antidiabetic drug development are commended [107]. Most of the plants that have high percentage of polyphenolic compounds have been widely used in cosmetics for their antiaging properties [102]. Based on Article 16d(1), Article 16f and Article 16h of Directive 2001/83/EC as amended (traditional use) Draft Herbal substance(s) (binomial scientific name of the plant, including plant part) Copyright © 2017 Iqra Sarfraz et al. The compiled data will hopefully update the scientific researchers with cotemporary endeavors in described field. In vitro evaluations of antitoxoplasma activity of oleuropein and its metabolites isolated from Fraxinus rhynchophylla showed a good efficacy and higher selectivity as an anti-T. gondii compound. Further research work is mandatory to fill the gaps by mainly focusing on the molecular targets of these plant extracts in extrinsic and intrinsic mitochondrial apoptosis pathways. Then, various pharmacological perspectives of Fraxinus plant such as proper dosage and clinical effectiveness are yet to be elucidated. Abietane extracted from Fraxinus sieboldiana exhibits cytotoxic activities against human ovarian A2780 cells and A549 (lung carcinoma) [57]. These cookies do not store any personal information. Zhao, J. Liu et al., “Molecular mechanisms of casticin action: An update on its antitumor functions,”, A. Rasul, B. Yu, L. Zhong, M. Khan, H. Yang, and T. Ma, “Cytotoxic effect of evodiamine in SGC-7901 human gastric adenocarcinoma cells via simultaneous induction of apoptosis and autophagy,”, A. Rasul, M. Khan, B. Yu, T. Ma, and H. Yang, “Xanthoxyletin, a coumarin induces S phase arrest and apoptosis in human gastric adenocarcinoma SGC-7901 cells,”, A. Rasul, C. Ding, X. Li et al., “Dracorhodin perchlorate inhibits PI3K/Akt and NF-, A. Rasul, B. Yu, M. Khan et al., “Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways,”, M. K. Urban, “COX-2 specific inhibitors offer improved advantages over traditional NSAIDs,”, K.-J. Abnobaviscum F extract specifically targets Mcl-1 at mRNA stage thus contributing to the activation of intrinsic caspase pathway. About 80% of the population globally depends upon the botanical drugs mainly from medicinal plants [8]. As folhas são verdes. Fraxetin showed protective activities against liver microsomal lipid peroxidation induced by Fe(+2) in rats with inhibitory rate of 60% at a concentration of 10(−6) mol × L(−1) [45]. Fraxinus excelsior, a novel herb, showed antiproliferative properties against numerous human cancerous cell lines: SKLC6 (lung carcinoma), AGS (Caucasian gastric adenocarcinoma), PLC/PRF/5 (liver hepatoma), SW742 (colorectal adenocarcinoma), A375 (melanoma cancer), and MCF-7 (breast ductal carcinoma) [55]. Mistletoe extract obtained from host tree Fraxinus showed cytotoxicity against various cancerous cells including chronic myeloid leukemia K562 cells, human multiple myeloma RPMI-8226 cells, and murine leukemia L1210 cells via JNK-1/2, caspase-9, and p38 MAPK activation, Mcl-1 downregulation, and inhibition of PKB and ERK-1/2 phosphorylation. Hepatoprotective activities by Fraxinus xanthoxyloides leave extract against carbon tetrachloride (CCl4) induced oxidative stress in hepatic tissues in rats (Rattus novergicus) reduce the level of H2O2 and significantly increase the regenerative capacity of liver antioxidant enzymes (CAT, POD, SOD, GST, and GSR) (EC50 = 400 mg/kg) [76]. Fraxinus excelsior Figure 1. It is also used as a tonic. Over the centuries, natural products from plants have proven their worth as a primary source of novel chemical entities having therapeutic potential [2]. Kim, H.-Y. Our aim is to update the scientific research community with recent endeavors with specifically highlighting the mechanism of action in different diseases. Similar Images . A study on herbal medicines has revealed that Fraxinus excelsior extract promotes diuresis and thus potentially can be used as hypotensive agent [109]. In vitro assessment of hydroxyframoside B isolated from ethanolic extract of stem bark of Fraxinus rhynchophylla provided an approach to decrease obesity via downregulating the pancreatic lipase activity thus restricting the absorption of lipid by pancreas [36]. An attempt to elucidate the mechanism of action of Fraxinus plant extract is that it increases the Bcl-2 expression, inhibits the translocation of mitochondrial apoptosis-inducing factor (AIF) to the cytoplasm, and decreases the Bax expression. Fraxinus plant extracts can serve as template for new drug design and synthesis of new compounds for various human diseases treatments. People take ash for fever, arthritis, gout, constipation, fluid retention, and bladder problems. Here, we have reviewed anticancer activities of Fraxinus plant with an intent to provide a clear image to researchers about this medically important plant. Among them, 49% of anticancer drugs belong to natural products [6, 7]. Lipopolysaccharide (LPS) and interferon-gamma induced murine macrophage-like RAW 264.7 cells treatment by Fraxinus rhynchophylla extract showed an inhibition trend towards the amount of iNOS protein in dose-dependent manner suggesting its possible application as anti-inflammatory agent in autoimmune and chronic inflammatory diseases [74]. The culpable compound should be subjected to isolation from extract and purified for further inquiry. Inhibitory concentration (IC50) reported to be 4.8 μM [57]. Yang, S.-I. Exogenous antioxidants primarily include natural as well as synthetic compounds having radical scavenging abilities. It is in leaf from May to October, in flower from April to May, and the seeds ripen from September to January. A range of chemical constituents including secoiridoids, phenylethanoids, lignans, flavonoids, and coumarins has been isolated from Fraxinus plant. Fraxini cortex, a traditional Chinese medicinal plant, possesses significant antidiarrheal properties having a notable effect on Cl(−) transport as simply the diarrhea is altered movement of Na+ and Cl− ions [108]. Some other biological activities of medically significant compounds isolated from Fraxinus species are as follows: diterpenes analogs from Fraxinus sieboldiana resulted in a prohibitory activity opposite to H5N1 avian influenza virus. Mechanism of action of Fraxinus plant is mainly associated with the upregulation of various antioxidant enzymes (Figure 3). Cell signaling pathways are the main pillars behind cell communication as they are essential for the regulation of cell proliferation and survival. Fraxinus plant extract and its isolated compounds have a potential to modulate the activity of various key enzymes associated with inflammatory response (Figure 3). Add to Likebox #62052850 - common ash tree isolated on white background. A. Rahuman et al., “Evaluation of antiplasmodial activity of medicinal plants from North Indian Buchpora and South Indian Eastern Ghats,”, K. C. Chinsembu, “Plants as antimalarial agents in Sub-Saharan Africa,”, B. Aydin-Schmidt, W. Thorsell, and M. Wahlgren, “Carolus linnaeus, the ash, worm-wood and other anti-malarial plants,”, J. C. Sepulveda-Arias, L. A. Veloza, and L. E. Mantilla-Muriel, “Anti-Toxoplasma activity of natural products: a review,”, Z. Y. Yu, B. D. Zhang, J. Y. Ning et al., “Advances in researches on mechanism of anti-Toxoplasma Chinese herbal medicine,”, T. Mizutani and H. Masaki, “Anti-photoaging capability of antioxidant extract from, J. Hubert, A. Angelis, N. Aligiannis et al., “In vitro dermo-cosmetic evaluation of bark extracts from common temperate trees,”, T. Ughetto, “Glucevia Fraxinus excelsior extract effectively controls blood glucose levels in randomized, controlled trial,”, M. A. Zulet, S. Navas-Carretero, D. Lara Y Sánchez et al., “A Fraxinus excelsior L. seeds/fruits extract benefits glucose homeostasis and adiposity related markers in elderly overweight/obese subjects: A longitudinal, randomized, crossover, double-blind, placebo-controlled nutritional intervention study,”, Z. Medjahed, D. Atmani-Kilani, M.-L. Fauconnier, G. Richard, and D. Atmani, “Hepatoprotective and antidiabetic activities of Fraxinus angustifolia Vahl extracts in animal models: Characterization by high performance liquid chromatography analysis,”, S. F. Abouzid, O. M. Ahmed, R. R. Ahmed, A. Mahmoud, E. Abdella, and M. B. Ashour, “Antihyperglycemic effect of crude extracts of some Egyptian plants and algae,”, J.-C. Tsai, S. Tsai, and W.-C. Chang, “Effect of ethanol extracts of three Chinese medicinal plants with anti-diarrheal properties on ion transport of the rat intestinal epithelia,”, C. I. Wright, L. van-Buren, C. I. Kroner, and M. M. G. Koning, “Herbal medicines as diuretics: a review of the scientific evidence,”. Screening of methanolic leave extracts from Fraxinus floribunda in rats suggests its significant pain relieving effects in inflammatory conditions [60]. The fruits of the fraxinus excelsior tree, called ash keys, have also been traditionally used by practitioners of herbal medicine for stomach disorders and indigestion.

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